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KMID : 0603520000050020094
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Journal of Korean Association of Cancer Prevention
2000 Volume.5 No. 2 p.94 ~ p.100
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Characteristics and Applicability of Apc Gene-mutated Mice in Chemopreventive Studies
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Ahn Byeong-Woo
Kim Dae-Joong
Jang Dong-Deuk
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Abstract
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It is generally recognized that rodent models for analysis and prevention of carcinogenesis can be classified into three categories, i.e., traditional chemical carcinogenic, chronic inflammatory, and transgenic or gene-knockout animal models. With our knowledges about basic mechanisms and etiology of human carcinogenesis, he transfer from traditional chemical carcinogenesis models to chronic inflammation of genetic model is now in fashion. Although the primary objective of the model developments is to elucidate the basic mechanism and etiology of carcinogenesis, those models are being adapted into chemoprevention studies and used for identifying potential chemopreventive agents. Mouse lines that harbor germ-line mutation in Apc gene such as ApcMin/+, ApcΔ716, ApcΔ474 and so forth are being considered to be useful animal models for investigating colorectal cancer chemopreventive agents because they bear similarities in molecular and genetic mechanisms to humans and, therefore, spontaneously develop numerous polyps in intestines, as in human familial adenomatous polyposis coli, and require realtively short period (12∼15 weeks) to develop grossly identifiable tumors. Even though the relevance or extrapolation of data from gene-mutated mice remains to be validated further, Apc gene-mutated mice model in practice would be more applicable in chemoprevention studies than any other gene-mutated models.
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KEYWORD
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Apc, Carcinogenesis, Chemoprevention, Gene-mutated animal model
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